Silicon Dioxide Nanoparticles

Last reviewed October 19, 2026

In plain words: This entry covers research on silicon dioxide (silica) particles in the nanometer size range, studied as nanoparticles. It is not the same as the food additive silicon dioxide (E 551); for that, see the silicon dioxide (E 551) page.

Also listed on labels as: Silica nanoparticles, SiO2 nanoparticles, Nano-silica

What do regulators say?

Regulatory status: This page covers research on a particle form; it is not a separately authorized food additive. For the food additive, see silicon dioxide (E 551).

Published research: what individual studies found

These are findings from individual published studies and food-safety agency opinions, credited to each paper. Each one is labeled by type of evidence. They do not change any verdict, evidence grade or score on this site.

Related exposure (not from eating food)

Exposure route: SiO2 nanoparticles

Evidence type: Animal (mouse, OECD-style fertility/early embryo study) · Study found no effect

In a mouse study, silicon dioxide nanoparticles given by mouth at up to 1,000 mg/kg did not cause significant effects on fertility, early embryo development or general health. The study tested nanoparticles, which may differ from food-grade E 551. The authors note remaining uncertainties. One animal study can't show how this applies to people.
Source: Jeong JS et al., Int J Nanomedicine, 2025 · doi:10.2147/ijn.s543070

For information only, not medical advice. Studies are cited to their authors' published papers; the researchers aren't affiliated with and don't endorse Let Me Scan That or any product. A study link doesn't mean an ingredient causes harm. Report an error

Related guides

Sources

Research covered: Jeong JS et al., Int J Nanomedicine, 2025, doi:10.2147/ijn.s543070. Link

This page is for general education. It is not medical advice and does not replace advice from your doctor, pediatrician, allergist or registered dietitian. Research changes; we review these pages when new evidence or rules come out. Last reviewed October 19, 2026.