Calcium Sulfate (E 516)

Last reviewed October 19, 2026

In plain words: Calcium sulfate (E 516) is food-grade gypsum. It conditions dough, firms canned vegetables, and is a standard coagulant for tofu.

What the evidence review says

Calcium sulfate is food-grade gypsum, used to set tofu, condition dough and firm canned vegetables. EFSA found sulfate exposure from these additives far below the level linked with a laxative effect in people, and no genotoxicity or cancer concern. EFSA recommended tighter limits on metal impurities.

No notable concern at reported food uses. EFSA found sulfate exposure from these additives far below the human dose associated with a laxative effect and saw no genotoxicity or carcinogenicity concern. High total calcium intake remains a general nutrient issue. Specifications should limit metal impurities.

• Source: EFSA Panel on Food Additives and Flavourings (FAF), EFSA J, 2019 · doi:10.2903/j.efsa.2019.5868

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This page is for general education. It is not medical advice and does not replace advice from your doctor, pediatrician, allergist or registered dietitian. Research changes; we review these pages when new evidence or rules come out. Last reviewed October 19, 2026.