Allulose

Last reviewed October 19, 2026

In plain words: Allulose is a rare sugar that tastes sweet but provides very few calories.

What the evidence review says

Allulose is a rare sugar that tastes sweet but provides very few calories. Studies have linked higher intakes with digestive effects such as diarrhea, bloating and stomach pain, and these become more common as the amount goes up.

The documented human effect at higher intakes is digestive: diarrhea, bloating and stomach pain. In a small, non-randomized study of healthy young adults (Han et al., Nutrients, 2018, doi:10.3390/nu10122010), symptoms became more common as the single dose and the total daily amount were raised, and were more frequent than with the same amount of sugar. These are study observations about tolerance, not an intake recommendation. U.S. GRAS notices have received FDA 'no questions' letters. In the EU it is a novel food. In June 2025 EFSA said safety of one D-allulose dossier could not be established because the applicant did not supply requested data on identity, production, uses, genotoxicity, and human data. That is a data-gap conclusion, not a finding that allulose was shown to be toxic.

• Source: Han Y et al., Nutrients, 2018 · doi:10.3390/nu10122010

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This page is for general education. It is not medical advice and does not replace advice from your doctor, pediatrician, allergist or registered dietitian. Research changes; we review these pages when new evidence or rules come out. Last reviewed October 19, 2026.